Potential impact of replacing SCORE with SCORE-2 on risk classification and statin eligibility – a coronary calcium score correlation study

Abstract Background Recently, the European Society of Cardiology issued new algorithms to estimate 10-year risk atherosclerotic cardiovascular disease (ASCVD), along with age-specific thresholds classify individuals as low-to-moderate, high, or very-high risk. The aim this study was compare latest SCORE-2 model older SCORE (Systematic COronary Risk Evaluation) in their ability identify high coronary artery calcium score (CACS), and assess relationship between potential eligibility for statin therapy CACS. Methods Individuals 40–69 years old without diabetes known ASCVD were identified a single center registry patients undergoing CACS CT angiography suspected disease. calculated used each patient's untreated LDL-C values therapy. High defined an Agatston ≥100. Results A total 389 pts (46% men, mean age 58±8 years) included, which 15% (n=60) active smokers. systolic blood pressure 136±17 mmHg 155±65 mg/dL, respectively. proportion classified low-to-moderate risk, very 93%, 6% 1% using algorithm, 42%, 44%, 14% SCORE-2, Overall, 218 (56%) would have category revised upwards, while no be downgraded. median 5 (IQR 0–71 AU), 166 (43%) having = 0, 81 (21%) presenting showed similar discriminative power ≥100 (C-statistic 0.77, 95% CI 0.71–0.82, vs. 0.75, 0.69–0.80, P=0.109 comparison]. up-reclassification conveyed by affected across all categories (Fig. 1). whom generally indicated higher criteria algorithm (61% 29%, respectively, p<0.001). broadening indication spanned CACS, including 0 2). Conclusion Even though is SCORE, introduction results roughly half patients. application will broaden overall, not only burden, but also those 0. These findings support use modifiers selected improve effectiveness Funding Acknowledgement Type funding sources: None.